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M94A3024.TXT
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1994-10-25
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Document 3024
DOCN M94A3024
TI On the epidemiologic association between endemic Kaposi's sarcoma and
malaria.
DT 9412
AU Baumann S; Geier SA; Noehl MA; Goebel FD; Medizinische Poliklinik, LMU,
Munich, Germany.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):170 (abstract no. PB0107). Unique
Identifier : AIDSLINE ICA10/94369551
AB OBJECTIVE: Kaposi's sarcoma (KS) is a frequent tumor in subsaharan
Africa (= endemic KS), and in patients with the acquired
immunodeficiency syndrome (= AIDS-associated KS). Endemic KS has been
attributed to environmental factors. The purpose of this study was to
look for an association between endemic KS and malaria. PATIENTS AND
METHODS: The literature was reviewed for data on proportional rates of
endemic KS in Africa. The presence of malaria transmission (yes versus
no) in countries in which data on KS were available was obtained from
the WHO. RESULTS: In 27 African countries data on the proportional rates
of endemic KS (range 0.04 per cent to 12.8 per cent) were available. The
proportional rate of KS in African countries was significantly
associated with the presence of malaria transmission (r = 0.44; p =
0.01). CONCLUSION: These data demonstrate a geographical association
between endemic KS and malaria. Therefore, malaria-induced
immunosuppression might be an additional cofactor in the pathogenesis of
endemic KS. In addition, abnormalities of cell-adhesion observed as
blood-flow sludging in patients with AIDS-associated KS as well as in
patients with malaria might contribute to the pathogenesis of both
AIDS-associated and endemic KS. It furthermore might become feasible
that the putative KS infectious agent is arthropod-borne in Africa.
DE Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY Africa South of the
Sahara/EPIDEMIOLOGY Causality Cross-Sectional Studies Human
Incidence Malaria/*EPIDEMIOLOGY Sarcoma, Kaposi's/*EPIDEMIOLOGY Skin
Neoplasms/*EPIDEMIOLOGY Support, Non-U.S. Gov't MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).